Version 5.4
Mus musculus Protein: Otp
Summary
InnateDB Protein IDBP-173510.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Otp
Protein Name orthopedia homolog (Drosophila)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000022195
InnateDB Gene IDBG-173508 (Otp)
Protein Structure
UniProt Annotation
Function Involved in the specification of hypothalamic neuroendocrine cells. Specifically required for the specification of diencephalic dopaminergic neurons of the A11 group. {ECO:0000269PubMed:10557207, ECO:0000269PubMed:11071765, ECO:0000269PubMed:17481897, ECO:0000269PubMed:7913821}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00108, ECO:0000255PROSITE-ProRule:PRU00138}.
Disease Associations
Tissue Specificity Restricted regions of the developing forebrain, hindbrain, and spinal cord. {ECO:0000269PubMed:7913821}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0002052 positive regulation of neuroblast proliferation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0021879 forebrain neuron differentiation
GO:0021979 hypothalamus cell differentiation
GO:0021985 neurohypophysis development
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:99835
InterPro IPR000047 Helix-turn-helix motif
IPR001356 Homeobox domain
IPR003654 OAR domain
IPR009057 Homeodomain-like
PFAM PF00046
PF03826
PRINTS PR00031
PIRSF
SMART SM00389
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O09113
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 18420
UniGene Mm.42051
RefSeq NP_035151
MGI ID
MGI Symbol Otp
OMIM
CCDS CCDS26695
HPRD
IMGT
EMBL Y10413
GenPept CAA71439

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca