Version 5.4
Mus musculus Protein: Cnnm2
Summary
InnateDB Protein IDBP-173620.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cnnm2
Protein Name cyclin M2
Synonyms Acdp2; AU015877; AW048635; Clp2;
Species Mus musculus
Ensembl Protein ENSMUSP00000096972
InnateDB Gene IDBG-173616 (Cnnm2)
Protein Structure
UniProt Annotation
Function Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+). {ECO:0000269PubMed:15899945}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:22399287}; Multi-pass membrane protein {ECO:0000269PubMed:22399287}.
Disease Associations
Tissue Specificity Widely expressed, with highest levels in kidney, lung, spleen and testis. In the kidney, predominantly expressed in the distal convoluted tubule and, at lower levels, in the connecting tubule (at protein level). {ECO:0000269PubMed:14723793, ECO:0000269PubMed:15899945, ECO:0000269PubMed:22399287}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0030554 adenyl nucleotide binding
Biological Process
GO:0010960 magnesium ion homeostasis
GO:0015693 magnesium ion transport
Cellular Component
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
Protein Structure and Domains
PDB ID MGI:2151054
InterPro IPR002550 Domain of unknown function DUF21
IPR018490 Cyclic nucleotide-binding-like
PFAM PF01595
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3TWN3
PhosphoSite PhosphoSite-Q3TWN3
TrEMBL
UniProt Splice Variant
Entrez Gene 94219
UniGene Mm.418583
RefSeq NP_291047
MGI ID
MGI Symbol Cnnm2
OMIM
CCDS CCDS50459
HPRD
IMGT
EMBL AC122442 AC161865 AF216961 AK044400 AK159616 BC027387 BC052513
GenPept AAF86373 AAH27387 AAH52513 BAC31904 BAE35233

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca