InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bach1

Summary

InnateDB Protein

IDBP-173701.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bach1

Protein Name

BTB and CNC homology 1

Synonyms

6230421P05Rik; AI323795;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026703

InnateDB Gene

IDBG-173699 (Bach1)

Protein Structure

UniProt Annotation

Function

Transcriptional regulator that acts as repressor or activator. Binds, in vitro, to NF-E2 binding sites. Play important roles in coordinating transcription activation and repression by MAFK. {ECO:0000269PubMed:19170764}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	23 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001206	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000117	regulation of transcription involved in G2/M transition of mitotic cell cycle
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

MGI:894680

InterPro

IPR000210 BTB/POZ-like
IPR004827 Basic-leucine zipper domain
IPR008917 Transcription factor, Skn-1-like, DNA-binding domain
IPR011333 BTB/POZ fold
IPR013069 BTB/POZ

PFAM

PF00170
PF07716
PF00651

PRINTS

PIRSF

SMART

SM00225
SM00338

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P97302