InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Uaca

Summary

InnateDB Protein

IDBP-173917.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Uaca

Protein Name

uveal autoantigen with coiled-coil domains and ankyrin repeats

Synonyms

2700059D02Rik; nucling;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000062047

InnateDB Gene

IDBG-173915 (Uaca)

Protein Structure

UniProt Annotation

Function

Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1. {ECO:0000269PubMed:14961764, ECO:0000269PubMed:15271982}.Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:12761289}. Cytoplasm {ECO:0000269PubMed:12761289}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:12761289}. Note=Expressed diffusely in cytoplasm.

Disease Associations

Tissue Specificity

Highly expressed in heart, liver, kidney and testis. Weakly expressed in lung and skeletal muscle. Not expressed in brain and spleen. {ECO:0000269PubMed:12761289}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009411	response to UV
GO:0042307	positive regulation of protein import into nucleus
GO:0042347	negative regulation of NF-kappaB import into nucleus
GO:0043065	positive regulation of apoptotic process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0050728	negative regulation of inflammatory response

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0016020	membrane
GO:0043293	apoptosome
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome