InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HMG20B

Summary

InnateDB Protein

IDBP-17412.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HMG20B

Protein Name

high mobility group 20B

Synonyms

BRAF25; BRAF35; HMGX2; HMGXB2; PP7706; pp8857; SMARCE1r; SOXL;

Species

Homo sapiens

Ensembl Protein

ENSP00000328269

InnateDB Gene

IDBG-17410 (HMG20B)

Protein Structure

UniProt Annotation

Function

Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters.

Subcellular Localization

Nucleus. Chromosome. Note=Localized to condensed chromosomes in mitosis in conjunction with BRCA2.

Disease Associations

Tissue Specificity

Ubiquitously expressed in adult tissues. {ECO:0000269PubMed:10773667, ECO:0000269PubMed:11997092}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	32 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007049	cell cycle
GO:0007596	blood coagulation
GO:0016568	chromatin modification
GO:0033234	negative regulation of protein sumoylation
GO:0035914	skeletal muscle cell differentiation
GO:0045666	positive regulation of neuron differentiation