InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Polr2b

Summary

InnateDB Protein

IDBP-174134.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Polr2b

Protein Name

polymerase (RNA) II (DNA directed) polypeptide B

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031167

InnateDB Gene

IDBG-174132 (Polr2b)

Protein Structure

UniProt Annotation

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 67 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	67 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001055	RNA polymerase II activity
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003899	DNA-directed RNA polymerase activity
GO:0005515	protein binding
GO:0032549	ribonucleoside binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter

Cellular Component

GO:0005634	nucleus
GO:0005665	DNA-directed RNA polymerase II, core complex
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:2388280

InterPro

IPR007120 DNA-directed RNA polymerase, subunit 2, domain 6
IPR007641 RNA polymerase Rpb2, domain 7
IPR007642 RNA polymerase Rpb2, domain 2
IPR007644 RNA polymerase, beta subunit, protrusion
IPR007645 RNA polymerase Rpb2, domain 3
IPR007646 RNA polymerase Rpb2, domain 4
IPR007647 RNA polymerase Rpb2, domain 5

PFAM