InnateDB Protein
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IDBP-174168.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Hint1
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Protein Name
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histidine triad nucleotide binding protein 1
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Synonyms
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AA673479; Hint; Ipk1; PKCI-1; PRKCNH1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000020504
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InnateDB Gene
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IDBG-174166 (Hint1)
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Protein Structure
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Function |
Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His- AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O- phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin- protein ligase complex (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm. Nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
14 [view]
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Molecular Function |
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Biological Process |
GO:0006351
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transcription, DNA-templated
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0009154
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purine ribonucleotide catabolic process
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GO:0072332
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intrinsic apoptotic signaling pathway by p53 class mediator
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Cellular Component |
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PDB ID |
MGI:1321133
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InterPro |
IPR001310
Histidine triad (HIT) protein
IPR011146
HIT-like domain
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PFAM |
PF01230
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PRINTS |
PR00332
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P70349
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PhosphoSite |
PhosphoSite-P70349
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
15254
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UniGene |
Mm.471974
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RefSeq |
NP_032274
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MGI ID |
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MGI Symbol |
Hint1
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OMIM |
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CCDS |
CCDS24702
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HPRD |
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IMGT |
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EMBL |
AK002965
AK012433
BC070415
BC080296
U60001
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GenPept |
AAC71076
AAH70415
AAH80296
BAB22484
BAB28235
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