Version 5.4
Mus musculus Protein: Gpx3
Summary
InnateDB Protein IDBP-174478.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gpx3
Protein Name glutathione peroxidase 3
Synonyms AA960521; EGPx; GPx; GSHPx-3; GSHPx-P;
Species Mus musculus
Ensembl Protein ENSMUSP00000081011
InnateDB Gene IDBG-174476 (Gpx3)
Protein Structure
UniProt Annotation
Function Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Secreted in plasma.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004602 glutathione peroxidase activity
GO:0008430 selenium binding
Biological Process
GO:0006979 response to oxidative stress
GO:0042744 hydrogen peroxide catabolic process
GO:0051289 protein homotetramerization
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:105102
InterPro IPR000889 Glutathione peroxidase
IPR012336 Thioredoxin-like fold
PFAM PF00255
PF13098
PF13192
PF13462
PF13905
PRINTS PR01011
PIRSF PIRSF000303
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P46412
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 14778
UniGene
RefSeq NP_032187
MGI ID
MGI Symbol Gpx3
OMIM
CCDS CCDS24703
HPRD
IMGT
EMBL AK002219 AK004942 AK146760 BC003339 BC037027 BC049235 BC061950 U13705 X84742
GenPept AAA62283 AAH03339 AAH37027 AAH49235 AAH61950 BAC55243 BAC55250 BAE27413

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca