InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pbk

Summary

InnateDB Protein

IDBP-174522.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pbk

Protein Name

PDZ binding kinase

Synonyms

2810434B10Rik; AW538537; D14Ertd732e; TOPK;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022612

InnateDB Gene

IDBG-174520 (Pbk)

Protein Structure

UniProt Annotation

Function

Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001933	negative regulation of protein phosphorylation
GO:0006468	protein phosphorylation
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032873	negative regulation of stress-activated MAPK cascade
GO:0034644	cellular response to UV
GO:0050728	negative regulation of inflammatory response

Cellular Component

GO:0005575

cellular_component

Protein Structure and Domains

PDB ID

MGI:1289156

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt