Version 5.4
Mus musculus Protein: Rnf11
Summary
InnateDB Protein IDBP-174579.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rnf11
Protein Name ring finger protein 11
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000063798
InnateDB Gene IDBG-174575 (Rnf11)
Protein Structure
UniProt Annotation
Function Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.
Subcellular Localization Early endosome {ECO:0000250}. Recycling endosome {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic, when unphosphorylated, and nuclear, when phosphorylated by PKB/AKT1. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 65 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 65 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005769 early endosome
GO:0055037 recycling endosome
Protein Structure and Domains
PDB ID MGI:1352759
InterPro IPR001841 Zinc finger, RING-type
IPR018957 Zinc finger, C3HC4 RING-type
PFAM PF13639
PF14634
PF00097
PRINTS
PIRSF
SMART SM00184
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9QYK7
PhosphoSite PhosphoSite-Q9QYK7
TrEMBL Z4YLT8
UniProt Splice Variant
Entrez Gene 29864
UniGene Mm.490560
RefSeq
MGI ID
MGI Symbol Rnf11
OMIM
CCDS CCDS18464
HPRD
IMGT
EMBL AB024427 AF220206 AL627446 AL669905 BC010299 BC028255 CH466527
GenPept AAG44245 AAH10299 AAH28255 BAA84682 CAM13662 CAM13663 EDL30703 EDL30704 EDL30705

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca