Version 5.4
Mus musculus Protein: Glce
Summary
InnateDB Protein IDBP-174602.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Glce
Protein Name glucuronyl C5-epimerase
Synonyms 1110017N23Rik; AI747411; C130034A12Rik; Hsepi;
Species Mus musculus
Ensembl Protein ENSMUSP00000034785
InnateDB Gene IDBG-174600 (Glce)
Protein Structure
UniProt Annotation
Function Converts D-glucuronic acid residues adjacent to N- sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins. {ECO:0000269PubMed:11274177, ECO:0000269PubMed:11279150, ECO:0000269PubMed:16532012, ECO:0000269PubMed:20208005}.
Subcellular Localization Golgi apparatus membrane {ECO:0000269PubMed:11279150}; Single-pass type II membrane protein {ECO:0000269PubMed:11279150}.
Disease Associations
Tissue Specificity Widely expressed with highest levels in lung and lowest levels in spleen. {ECO:0000269PubMed:11274177}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives
GO:0047464 heparosan-N-sulfate-glucuronate 5-epimerase activity
GO:0050379 UDP-glucuronate 5'-epimerase activity
Biological Process
GO:0006024 glycosaminoglycan biosynthetic process
GO:0015012 heparan sulfate proteoglycan biosynthetic process
GO:0030210 heparin biosynthetic process
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2136405
InterPro IPR010598 D-glucuronyl C5-epimerase
PFAM PF06662
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9EPS3
PhosphoSite PhosphoSite-Q9EPS3
TrEMBL Q69ZY0
UniProt Splice Variant
Entrez Gene 93683
UniGene Mm.401709
RefSeq NP_201577
MGI ID
MGI Symbol Glce
OMIM
CCDS CCDS23262
HPRD
IMGT
EMBL AF325532 AF330049 AK173038 BC094587 CH466522
GenPept AAG42004 AAH94587 AAK26246 BAD32316 EDL26018

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca