InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Faf1

Summary

InnateDB Protein

IDBP-174696.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Faf1

Protein Name

Fas-associated factor 1

Synonyms

AA408698; Dffrx; Fam;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099785

InnateDB Gene

IDBG-174694 (Faf1)

Protein Structure

UniProt Annotation

Function

Potentiates but cannot initiate FAS-induced apoptosis.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 67 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	67 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0019904	protein domain specific binding
GO:0031072	heat shock protein binding
GO:0031625	ubiquitin protein ligase binding
GO:0043130	ubiquitin binding
GO:0051059	NF-kappaB binding

Biological Process

GO:0006915	apoptotic process
GO:0007253	cytoplasmic sequestering of NF-kappaB
GO:0008219	cell death
GO:0030155	regulation of cell adhesion
GO:0031334	positive regulation of protein complex assembly
GO:0042176	regulation of protein catabolic process
GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0034098	Cdc48p-Npl4p-Ufd1p AAA ATPase complex
GO:0048471	perinuclear region of cytoplasm