InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gm2a

Summary

InnateDB Protein

IDBP-174818.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gm2a

Protein Name

GM2 ganglioside activator protein

Synonyms

AA408702; AW215435; GM2-AP; SAP-3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000000608

InnateDB Gene

IDBG-174816 (Gm2a)

Protein Structure

UniProt Annotation

Function

Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity. {ECO:0000269PubMed:16216074}.

Subcellular Localization

Lysosome.

Disease Associations

Tissue Specificity

Widely expressed. Most abundant in kidney and testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004563	beta-N-acetylhexosaminidase activity
GO:0005319	lipid transporter activity
GO:0008047	enzyme activator activity
GO:0016004	phospholipase activator activity
GO:0032428	beta-N-acetylgalactosaminidase activity

Biological Process

GO:0001573	ganglioside metabolic process
GO:0006689	ganglioside catabolic process
GO:0006869	lipid transport
GO:0007611	learning or memory
GO:0009313	oligosaccharide catabolic process
GO:0019915	lipid storage
GO:0050877	neurological system process
GO:0050885	neuromuscular process controlling balance
GO:0051345	positive regulation of hydrolase activity

Cellular Component

GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005764	lysosome
GO:0005889	hydrogen:potassium-exchanging ATPase complex
GO:0009898	cytoplasmic side of plasma membrane
GO:0045179	apical cortex
GO:0070062	extracellular vesicular exosome