Version 5.4
Homo sapiens Protein: P2RX5
Summary
InnateDB Protein IDBP-17486.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol P2RX5
Protein Name purinergic receptor P2X, ligand-gated ion channel, 5
Synonyms LRH-1; P2X5; P2X5R;
Species Homo sapiens
Ensembl Protein ENSP00000225328
InnateDB Gene IDBG-17474 (P2RX5)
Protein Structure
UniProt Annotation
Function Receptor for ATP that acts as a ligand-gated ion channel.
Subcellular Localization Membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Expressed at high levels in brain and immune system.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001614 purinergic nucleotide receptor activity
GO:0004888 transmembrane signaling receptor activity
GO:0004931 extracellular ATP-gated cation channel activity
GO:0005216 ion channel activity
GO:0005524 ATP binding
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006812 cation transport
GO:0007165 signal transduction
GO:0007399 nervous system development
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0034220 ion transmembrane transport
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0050850 positive regulation of calcium-mediated signaling
Cellular Component
GO:0005639 integral component of nuclear inner membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR001429 P2X purinoreceptor
IPR003048 P2X5 purinoceptor
PFAM PF00864
PRINTS PR01307
PR01312
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q93086
PhosphoSite PhosphoSite-Q93086
TrEMBL
UniProt Splice Variant
Entrez Gene 5026
UniGene
RefSeq NP_002552
HUGO HGNC:8536
OMIM 602836
CCDS CCDS11034
HPRD 09110
IMGT
EMBL AB209623 AC132942 AF016709 AF070573 AF168787 AK290889 AK307959 BC028084 BC039015 CH471108 DQ234349 U49395 U49396
GenPept AAB08576 AAB08577 AAC28645 AAC51931 AAF43105 AAF43106 AAH39015 ABB29978 BAD92860 BAF83578 EAW90483

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca