InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fem1b

Summary

InnateDB Protein

IDBP-174909.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fem1b

Protein Name

feminization 1 homolog b (C. elegans)

Synonyms

mKIAA0396;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034775

InnateDB Gene

IDBG-174907 (Fem1b)

Protein Structure

UniProt Annotation

Function

Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15601915}. Nucleus {ECO:0000250}. Note=Associated with chromatin. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in pancreatic islets, within both beta cells and non-beta cells (at protein level). Highly expressed in adult testis. {ECO:0000269PubMed:9828124}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005123	death receptor binding
GO:0005515	protein binding

Biological Process

GO:0002070	epithelial cell maturation
GO:0006915	apoptotic process
GO:0016567	protein ubiquitination
GO:0051438	regulation of ubiquitin-protein ligase activity
GO:0060442	branching involved in prostate gland morphogenesis
GO:0060743	epithelial cell maturation involved in prostate gland development
GO:1902041	regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000001	regulation of DNA damage checkpoint