InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mrap

Summary

InnateDB Protein

IDBP-174949.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mrap

Protein Name

melanocortin 2 receptor accessory protein

Synonyms

1110025G12Rik; Falp; ORF61;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000043890

InnateDB Gene

IDBG-174947 (Mrap)

Protein Structure

UniProt Annotation

Function

Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context. Upon insulin stimulation, it is redistributed into spotty structures throughout the cytoplasm (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Largely restricted to fat tissues. Predominantly expressed in mouse epididymal (white adipose tissue) and interscapular (brown adipose tissue) fat pads. Expression is weak or absent in lung, spleen, intestine, kidney, heart and skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0031780	corticotropin hormone receptor binding
GO:0031781	type 3 melanocortin receptor binding
GO:0031782	type 4 melanocortin receptor binding
GO:0031783	type 5 melanocortin receptor binding
GO:0070996	type 1 melanocortin receptor binding