InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ephx2

Summary

InnateDB Protein

IDBP-174964.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ephx2

Protein Name

epoxide hydrolase 2, cytoplasmic

Synonyms

CEH; Eph2; SEH; sEP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000069209

InnateDB Gene

IDBG-174962 (Ephx2)

Protein Structure

UniProt Annotation

Function

Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo- 9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro- 9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy- octadec-9Z-enoic acid, 12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Peroxisome.

Disease Associations

Tissue Specificity

Detected in liver, intestine, ovary and kidney. Detected at low levels in heart and muscle. {ECO:0000269PubMed:15601917, ECO:0000269PubMed:8750907}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004301	epoxide hydrolase activity
GO:0005102	receptor binding
GO:0015643	toxic substance binding
GO:0016787	hydrolase activity
GO:0016791	phosphatase activity
GO:0033885	10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity
GO:0042577	lipid phosphatase activity

Biological Process

GO:0008152	metabolic process
GO:0009636	response to toxic substance
GO:0010628	positive regulation of gene expression
GO:0016311	dephosphorylation
GO:0042632	cholesterol homeostasis
GO:0046272	stilbene catabolic process
GO:0046839	phospholipid dephosphorylation
GO:0090181	regulation of cholesterol metabolic process

Cellular Component

GO:0005730	nucleolus
GO:0005777	peroxisome
GO:0005794	Golgi apparatus
GO:0005925	focal adhesion
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:99500

InterPro

IPR000073 Alpha/beta hydrolase fold-1
IPR000639 Epoxide hydrolase-like
IPR006439 HAD hydrolase, subfamily IA
IPR023214 HAD-like domain
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF00561
PF00702
PF08282
PF13419

PRINTS

PR00111
PR00412
PR00413

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P34914