InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cav3

Summary

InnateDB Protein

IDBP-175056.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cav3

Protein Name

caveolin 3

Synonyms

AI385751; Cav-3; M-cav;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000074922

InnateDB Gene

IDBG-175054 (Cav3)

Protein Structure

UniProt Annotation

Function

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. {ECO:0000269PubMed:19380584}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Membrane, caveola {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed predominantly in muscle. {ECO:0000269PubMed:8521953}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005246	calcium channel regulator activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0017080	sodium channel regulator activity
GO:0019870	potassium channel inhibitor activity
GO:0019899	enzyme binding
GO:0032403	protein complex binding
GO:0032947	protein complex scaffold
GO:0043014	alpha-tubulin binding
GO:0044325	ion channel binding
GO:0050998	nitric-oxide synthase binding
GO:0071253	connexin binding

Biological Process

GO:0001778	plasma membrane repair
GO:0002027	regulation of heart rate
GO:0006469	negative regulation of protein kinase activity
GO:0006641	triglyceride metabolic process
GO:0006897	endocytosis
GO:0007009	plasma membrane organization
GO:0007015	actin filament organization
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007520	myoblast fusion
GO:0008016	regulation of heart contraction
GO:0008104	protein localization
GO:0008284	positive regulation of cell proliferation
GO:0010614	negative regulation of cardiac muscle hypertrophy
GO:0010831	positive regulation of myotube differentiation
GO:0014819	regulation of skeletal muscle contraction
GO:0014902	myotube differentiation
GO:0016049	cell growth
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
GO:0030154	cell differentiation
GO:0031116	positive regulation of microtubule polymerization
GO:0031122	cytoplasmic microtubule organization
GO:0031579	membrane raft organization
GO:0038009	regulation of signal transduction by receptor internalization
GO:0042391	regulation of membrane potential
GO:0042593	glucose homeostasis
GO:0042632	cholesterol homeostasis
GO:0043407	negative regulation of MAP kinase activity
GO:0043409	negative regulation of MAPK cascade
GO:0045792	negative regulation of cell size
GO:0046716	muscle cell cellular homeostasis
GO:0051001	negative regulation of nitric-oxide synthase activity
GO:0051394	regulation of nerve growth factor receptor activity
GO:0051647	nucleus localization
GO:0051896	regulation of protein kinase B signaling
GO:0051924	regulation of calcium ion transport
GO:0051926	negative regulation of calcium ion transport
GO:0055013	cardiac muscle cell development
GO:0055117	regulation of cardiac muscle contraction
GO:0060299	negative regulation of sarcomere organization
GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization
GO:0060347	heart trabecula formation
GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization
GO:0060762	regulation of branching involved in mammary gland duct morphogenesis
GO:0061052	negative regulation of cell growth involved in cardiac muscle cell development
GO:0070836	caveola assembly
GO:0072659	protein localization to plasma membrane
GO:0086005	ventricular cardiac muscle cell action potential
GO:0090002	establishment of protein localization to plasma membrane
GO:0090279	regulation of calcium ion import
GO:1900744	regulation of p38MAPK cascade
GO:1900825	regulation of membrane depolarization during cardiac muscle cell action potential
GO:1901017	negative regulation of potassium ion transmembrane transporter activity
GO:1901019	regulation of calcium ion transmembrane transporter activity
GO:1901380	negative regulation of potassium ion transmembrane transport
GO:2000649	regulation of sodium ion transmembrane transporter activity
GO:2001288	positive regulation of caveolin-mediated endocytosis

Cellular Component

GO:0000139	Golgi membrane
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0005901	caveola
GO:0009986	cell surface
GO:0014704	intercalated disc
GO:0016010	dystrophin-associated glycoprotein complex
GO:0016020	membrane
GO:0030018	Z disc
GO:0030315	T-tubule
GO:0031594	neuromuscular junction
GO:0031982	vesicle
GO:0042383	sarcolemma
GO:0043234	protein complex
GO:0045121	membrane raft