InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ttc21b

Summary

InnateDB Protein

IDBP-175097.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ttc21b

Protein Name

tetratricopeptide repeat domain 21B

Synonyms

2410066K11Rik; aln; mKIAA1992; Thm1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099779

InnateDB Gene

IDBG-175095 (Ttc21b)

Protein Structure

UniProt Annotation

Function

Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Negatively modulates the SHH signal transduction. {ECO:0000269PubMed:18327258}.

Subcellular Localization

Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269PubMed:18327258}. Note=In polarized epithelial inner medullary collecting ducts cells and in the nodes of mice at 8.0 dpc, colocalizes with alpha-tubulin in cilia. Expressed in a punctate manner throughout the axoneme from the cilia base to the tip.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007224	smoothened signaling pathway
GO:0008589	regulation of smoothened signaling pathway
GO:0021591	ventricular system development
GO:0021798	forebrain dorsal/ventral pattern formation
GO:0035721	intraciliary retrograde transport
GO:0035735	intraciliary transport involved in cilium morphogenesis
GO:0060271	cilium morphogenesis
GO:0061512	protein localization to cilium