InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ifnar2

Summary

InnateDB Protein

IDBP-175858.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ifnar2

Protein Name

interferon (alpha and beta) receptor 2

Synonyms

AI747302; Ifnar-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023693

InnateDB Gene

IDBG-175856 (Ifnar2)

Protein Structure

UniProt Annotation

Function

Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 2 and 3 may be potent inhibitors of type I IFN receptor activity (By similarity). {ECO:0000250}.

Subcellular Localization

Isoform 1: Membrane; Single-pass type I membrane protein.Isoform 2: Secreted {ECO:0000305}.Isoform 3: Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Widely expressed. Detected in liver, testis, kidney, salivary gland, thymus, brain, lung and placenta. Isoform 1, isoform 2 and isoform 3 are expressed in brain. {ECO:0000269PubMed:9295335, ECO:0000269PubMed:9322767}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004905	type I interferon receptor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0019962	type I interferon binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0008283	cell proliferation
GO:0035455	response to interferon-alpha
GO:0060337	type I interferon signaling pathway