InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Msh5

Summary

InnateDB Protein

IDBP-175898.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Msh5

Protein Name

mutS homolog 5 (E. coli)

Synonyms

G7; Mut5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000007250

InnateDB Gene

IDBG-175896 (Msh5)

Protein Structure

UniProt Annotation

Function

Involved in meiotic recombination. Facilitate crossovers between homologs during meiosis (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding
GO:0008094	DNA-dependent ATPase activity
GO:0030983	mismatched DNA binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006298	mismatch repair
GO:0007127	meiosis I
GO:0007129	synapsis
GO:0007131	reciprocal meiotic recombination
GO:0007292	female gamete generation
GO:0045143	homologous chromosome segregation
GO:0051026	chiasma assembly

Cellular Component

GO:0000795	synaptonemal complex
GO:0005654	nucleoplasm

Protein Structure and Domains

PDB ID

MGI:1329021

InterPro

IPR000432 DNA mismatch repair protein MutS, C-terminal
IPR007696 DNA mismatch repair protein MutS, core
IPR007861 DNA mismatch repair protein MutS, clamp
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00488
PF05192
PF05190

PRINTS

PIRSF

SMART

SM00534
SM00533

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9QUM7