Version 5.4
Mus musculus Protein: Irs4
Summary
InnateDB Protein IDBP-175967.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Irs4
Protein Name insulin receptor substrate 4
Synonyms IRS-4;
Species Mus musculus
Ensembl Protein ENSMUSP00000067085
InnateDB Gene IDBG-175965 (Irs4)
Protein Structure
UniProt Annotation
Function Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269PubMed:10403832, ECO:0000269PubMed:10644546, ECO:0000269PubMed:11113178, ECO:0000269PubMed:12618213}.
Subcellular Localization Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Disease Associations
Tissue Specificity Expressed in skeletal muscle, brain, heart, kidney and liver. {ECO:0000269PubMed:10067860, ECO:0000269PubMed:10644546}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 33 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005158 insulin receptor binding
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID MGI:1338009
InterPro IPR001849 Pleckstrin homology domain
IPR002404 Insulin receptor substrate-1, PTB
PFAM PF00169
PF02174
PRINTS PR00628
PIRSF
SMART SM00233
SM00310
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Z0Y7
PhosphoSite PhosphoSite-Q9Z0Y7
TrEMBL
UniProt Splice Variant
Entrez Gene 16370
UniGene Mm.422287
RefSeq NP_034702
MGI ID
MGI Symbol Irs4
OMIM
CCDS CCDS30445
HPRD
IMGT
EMBL AF087797 AK045172 BX571779
GenPept AAD17797 BAC32246 CAM23732

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca