InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ins1

Summary

InnateDB Protein

IDBP-176191.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ins1

Protein Name

insulin I

Synonyms

Ins-1; Ins2-rs1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000049095

InnateDB Gene

IDBG-176189 (Ins1)

Protein Structure

UniProt Annotation

Function

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005158	insulin receptor binding
GO:0005179	hormone activity
GO:0051087	chaperone binding

Biological Process

GO:0006006	glucose metabolic process
GO:0010033	response to organic substance
GO:0015758	glucose transport
GO:0031018	endocrine pancreas development
GO:0034097	response to cytokine
GO:0043434	response to peptide hormone
GO:0051591	response to cAMP

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0030141	secretory granule
GO:0034774	secretory granule lumen