Version 5.4
| Mus musculus Protein: Dock5 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-176273.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Dock5 | ||||||||
| Protein Name | dedicator of cytokinesis 5 | ||||||||
| Synonyms | 1110060D06Rik; AI666732; AI956923; BC016533; E130320D18; lr2; rlc; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000036674 | ||||||||
| InnateDB Gene | IDBG-176271 (Dock5) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP. {ECO:0000269PubMed:18396277}. | ||||||||
| Subcellular Localization | Cytoplasm {ECO:0000269PubMed:18396277}. | ||||||||
| Disease Associations | Note=Defects in Dock5 are the cause of rupture of lens cataract. It affects both eyes and is inherited as an autosomal recessive trait. Homozygotes spontaneously develop opacity of the lens at 35-60 days of age. The initial pathological changes appear at about 35 days of age in the deep layer of the posterior cortex as irregular swelling, condensation, degeneration and fragmentation of the lens fibers, leading to rupture of the lens capsule at the posterior pole at 45-100 days of age. Following rupture, the lens nucleus becomes dislocated behind the lens or occasionally in the anterior chamber. {ECO:0000269PubMed:9093026, ECO:0000269PubMed:9230506}. | ||||||||
| Tissue Specificity | Highly expressed in lens, where it predominantly localizes to anterior epithelial cells, and is weakly expressed in lens fiber (at protein level). Expressed in brain, eye, lung, spleen and kidney, but not in thymus or peripheral blood leukocytes. {ECO:0000269PubMed:18396277}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:2652871 | ||||||||
| InterPro |
IPR000008
C2 domain IPR001452 SH3 domain IPR010703 Dedicator of cytokinesis C-terminal IPR011511 Variant SH3 domain IPR016024 Armadillo-type fold |
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| PFAM |
PF00168
PF00018 PF14604 PF06920 PF07653 |
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| PRINTS |
PR00360
PR00452 |
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| PIRSF | |||||||||
| SMART |
SM00239
SM00326 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | B2RY04 | ||||||||
| PhosphoSite | PhosphoSite-B2RY04 | ||||||||
| TrEMBL | Q91YL4 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 68813 | ||||||||
| UniGene | Mm.396775 | ||||||||
| RefSeq | NP_808448 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Dock5 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS36963 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AC090431 AC093020 BC016533 BC158046 BC158135 BC158138 | ||||||||
| GenPept | AAH16533 AAI58047 AAI58136 AAI58139 | ||||||||