Version 5.4
Mus musculus Protein: Megf11
Summary
InnateDB Protein IDBP-176385.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Megf11
Protein Name multiple EGF-like-domains 11
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000091349
InnateDB Gene IDBG-176379 (Megf11)
Protein Structure
UniProt Annotation
Function May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements. {ECO:0000269PubMed:22407321}.
Subcellular Localization Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Basolateral cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Forms an irregular, mosaic-like adhesion pattern in region of the cell that becomes firmely fixed to the substrate. Localized to protruding lamellipodia. Does not localize with MEGF10 (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0010842 retina layer formation
GO:0034109 homotypic cell-cell adhesion
Cellular Component
GO:0005575 cellular_component
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
Protein Structure and Domains
PDB ID MGI:1920951
InterPro IPR000742 Epidermal growth factor-like domain
IPR002049 EGF-like, laminin
IPR011489 EMI domain
IPR013111 EGF-like domain, extracellular
PFAM PF00008
PF00053
PF07546
PF07974
PRINTS
PIRSF
SMART SM00181
SM00180
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q80T91
PhosphoSite PhosphoSite-Q80T91
TrEMBL
UniProt Splice Variant
Entrez Gene 214058
UniGene Mm.127721
RefSeq NP_766110
MGI ID
MGI Symbol Megf11
OMIM
CCDS CCDS23281
HPRD
IMGT
EMBL AK048840 AK051642 AK122555 AK160406
GenPept BAC33471 BAC34702 BAC65837 BAE35774

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca