InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dhps

Summary

InnateDB Protein

IDBP-176554.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dhps

Protein Name

deoxyhypusine synthase

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000077733

InnateDB Gene

IDBG-176552 (Dhps)

Protein Structure

UniProt Annotation

Function

Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0034038	deoxyhypusine synthase activity

Biological Process

GO:0008612	peptidyl-lysine modification to peptidyl-hypusine
GO:0042102	positive regulation of T cell proliferation
GO:0042593	glucose homeostasis
GO:0050983	deoxyhypusine biosynthetic process from spermidine
GO:0051289	protein homotetramerization