InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mccc2

Summary

InnateDB Protein

IDBP-176731.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mccc2

Protein Name

methylcrotonoyl-Coenzyme A carboxylase 2 (beta)

Synonyms

4930552N12Rik; MCCB;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022148

InnateDB Gene

IDBG-176729 (Mccc2)

Protein Structure

UniProt Annotation

Function

Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3- methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. {ECO:0000250}.

Subcellular Localization

Mitochondrion matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004485	methylcrotonoyl-CoA carboxylase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016874	ligase activity

Biological Process

GO:0006552	leucine catabolic process
GO:0015936	coenzyme A metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

MGI:1925288

InterPro

IPR000022 Carboxyl transferase
IPR011762 Acetyl-coenzyme A carboxyltransferase, N-terminal
IPR011763 Acetyl-coenzyme A carboxyltransferase, C-terminal
IPR029045 ClpP/crotonase-like domain

PFAM

PF01039

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3ULD5

PhosphoSite