Mus musculus Protein: Lim2 | |||||||||
---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||
InnateDB Protein | IDBP-176794.6 | ||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
Gene Symbol | Lim2 | ||||||||
Protein Name | lens intrinsic membrane protein 2 | ||||||||
Synonyms | |||||||||
Species | Mus musculus | ||||||||
Ensembl Protein | ENSMUSP00000004732 | ||||||||
InnateDB Gene | IDBG-176792 (Lim2) | ||||||||
Protein Structure | |||||||||
UniProt Annotation | |||||||||
Function | Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis. | ||||||||
Subcellular Localization | Membrane; Multi-pass membrane protein. | ||||||||
Disease Associations | Note=Defects in Lim2 are the cause of the cataractous mouse mutant with total opacity of lens 3 (To3). Mice heterozygous or homozygous for the To3 mutation have total opacity of the lens with a dense cataract. In addition, the To3/To3 homozygotes exhibit microphthalmia, abnormally small eyes. | ||||||||
Tissue Specificity | |||||||||
Comments | |||||||||
Interactions | |||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
|
||||||||
Gene Ontology | |||||||||
Molecular Function |
|
||||||||
Biological Process |
|
||||||||
Cellular Component |
|
||||||||
Protein Structure and Domains | |||||||||
PDB ID | MGI:104698 | ||||||||
InterPro |
IPR003935
Lens fibre membrane intrinsic protein IPR004031 PMP-22/EMP/MP20/Claudin superfamily IPR004032 PMP-22/EMP/MP20 |
||||||||
PFAM |
PF00822
PF13903 |
||||||||
PRINTS |
PR01457
PR01453 |
||||||||
PIRSF | |||||||||
SMART | |||||||||
TIGRFAMs | |||||||||
Post-translational Modifications | |||||||||
Modification | |||||||||
Cross-References | |||||||||
SwissProt | P56563 | ||||||||
PhosphoSite | PhosphoSite-P56563 | ||||||||
TrEMBL | |||||||||
UniProt Splice Variant | |||||||||
Entrez Gene | 233187 | ||||||||
UniGene | |||||||||
RefSeq | NP_808361 | ||||||||
MGI ID | |||||||||
MGI Symbol | Lim2 | ||||||||
OMIM | |||||||||
CCDS | CCDS21168 | ||||||||
HPRD | |||||||||
IMGT | |||||||||
EMBL | AF320075 AK029354 AK164958 BC119253 BC119255 | ||||||||
GenPept | AAI19254 AAI19256 AAK08062 BAC26414 BAE37979 | ||||||||