InnateDB Protein
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IDBP-176949.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ncl
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Protein Name
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nucleolin
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Synonyms
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B530004O11Rik; C23; D0Nds28; D1Nds28; Nucl;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000027438
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InnateDB Gene
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IDBG-176947 (Ncl)
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Protein Structure
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Function |
Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus, nucleolus. Cytoplasm {ECO:0000250}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in B-cells that have been induced to switch to various Ig isotypes. {ECO:0000269PubMed:9642267}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 159 interaction(s) predicted by orthology.
Experimentally validated |
Total |
29
[view]
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Protein-Protein |
29
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
159 [view]
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Molecular Function |
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Biological Process |
GO:0001525
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angiogenesis
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GO:1901838
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positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
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Cellular Component |
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PDB ID |
MGI:97286
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InterPro |
IPR000504
RNA recognition motif domain
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PFAM |
PF00076
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PRINTS |
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PIRSF |
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SMART |
SM00360
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TIGRFAMs |
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Modification |
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SwissProt |
P09405
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PhosphoSite |
PhosphoSite-P09405
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
17975
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UniGene |
Mm.474153
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RefSeq |
NP_035010
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MGI ID |
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MGI Symbol |
Ncl
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OMIM |
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CCDS |
CCDS35646
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HPRD |
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IMGT |
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EMBL |
AF318184
AK050958
AK083307
AK144894
AK161706
AK163275
BC005460
M22089
X07699
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GenPept |
AAA39841
AAH05460
AAK07920
BAC34476
BAC38858
BAE26119
BAE36542
BAE37270
CAA30538
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