InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nkx3-1

Summary

InnateDB Protein

IDBP-177116.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nkx3-1

Protein Name

NK-3 transcription factor, locus 1 (Drosophila)

Synonyms

bagpipe; Bax; Nkx-3.1; NKX3.1; NKX3A;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022646

InnateDB Gene

IDBG-177114 (Nkx3-1)

Protein Structure

UniProt Annotation

Function

Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor (By similarity). Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to suppress growth and tumorigenicity of prostate carcinoma cells. Plays a role in the formation of minor salivary glands (particularly palatine and lingual glands). Essential for appropriate differentiation and secretory function of the bulbourethral gland. {ECO:0000250, ECO:0000269PubMed:12036903}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}.

Disease Associations

Tissue Specificity

Expressed mostly in the male urogenital tract, with highest expression in the epithelial cells lining the ducts of anterior, dorsolateral and ventral prostate and in the bulbourethral gland, and much lower in the seminal vesicle and the testis. Expression in the prostate increases during sexual maturation and is drastically reduced following castration. Expressed also in brain (hippocampus and external granular layer of the cerebral cortex), kidney (intralobular arteries), thymus and adrenal and salivary glands.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0000983	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity
GO:0001047	core promoter binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004882	androgen receptor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0030284	estrogen receptor activity
GO:0030295	protein kinase activator activity
GO:0030331	estrogen receptor binding
GO:0042826	histone deacetylase binding
GO:0043565	sequence-specific DNA binding
GO:0043621	protein self-association
GO:0044212	transcription regulatory region DNA binding
GO:0097162	MADS box domain binding

Biological Process

GO:0001655	urogenital system development
GO:0001656	metanephros development
GO:0001756	somitogenesis
GO:0001934	positive regulation of protein phosphorylation
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007431	salivary gland development
GO:0007507	heart development
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0008584	male gonad development
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0010942	positive regulation of cell death
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030521	androgen receptor signaling pathway
GO:0030850	prostate gland development
GO:0033574	response to testosterone
GO:0035260	internal genitalia morphogenesis
GO:0035690	cellular response to drug
GO:0035907	dorsal aorta development
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043401	steroid hormone mediated signaling pathway
GO:0043491	protein kinase B signaling
GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway
GO:0045860	positive regulation of protein kinase activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045930	negative regulation of mitotic cell cycle
GO:0045931	positive regulation of mitotic cell cycle
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048754	branching morphogenesis of an epithelial tube
GO:0050680	negative regulation of epithelial cell proliferation
GO:0051781	positive regulation of cell division
GO:0060037	pharyngeal system development
GO:0060442	branching involved in prostate gland morphogenesis
GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0071347	cellular response to interleukin-1
GO:0071356	cellular response to tumor necrosis factor
GO:0071383	cellular response to steroid hormone stimulus
GO:0071456	cellular response to hypoxia
GO:0071850	mitotic cell cycle arrest
GO:0071899	negative regulation of estrogen receptor binding
GO:2000836	positive regulation of androgen secretion
GO:2001022	positive regulation of response to DNA damage stimulus
GO:2001235	positive regulation of apoptotic signaling pathway
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway