InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc25a37

Summary

InnateDB Protein

IDBP-177143.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc25a37

Protein Name

solute carrier family 25, member 37

Synonyms

1700020E22Rik; 4930513O14Rik; 4930526G11Rik; AI848481; C330015G08Rik; frascati; Mfrn; Mfrn1; mitoferrin; Mscp;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000039990

InnateDB Gene

IDBG-177141 (Slc25a37)

Protein Structure

UniProt Annotation

Function

Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme. {ECO:0000269PubMed:16511496}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in hematopoietic organs, fetal liver, bone marrow and spleen. {ECO:0000269PubMed:11845285, ECO:0000269PubMed:16511496}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005381	iron ion transmembrane transporter activity

Biological Process

GO:0034755	iron ion transmembrane transport
GO:0048250	mitochondrial iron ion transport
GO:0055072	iron ion homeostasis

Cellular Component

GO:0005743	mitochondrial inner membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1914962

InterPro

IPR018108 Mitochondrial substrate/solute carrier
IPR023395 Mitochondrial carrier domain

PFAM

PF00153

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q920G8

PhosphoSite

PhosphoSite-

TrEMBL

Q9CQG7

UniProt Splice Variant

Entrez Gene

67712

UniGene

Mm.400542

RefSeq

NP_080607

MGI ID

MGI Symbol

Slc25a37

OMIM

CCDS

CCDS27238

HPRD

IMGT

EMBL

AF288621 AF361699 AK015770 AK015790 AK019700 AK021203 AK028588 AK050414 AK086749 AK162615 BC040399

GenPept

AAH40399 AAL23859 AAL27990 BAB29969 BAB29978 BAB31839 BAC25649 BAC26021 BAC34243 BAC39735 BAE36991