Version 5.4
Mus musculus Protein: Rufy3
Summary
InnateDB Protein IDBP-177281.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rufy3
Protein Name RUN and FYVE domain containing 3
Synonyms 2810428M05Rik; 6330416M07Rik; AW455998; AW538594; D5Bwg0860e; Ripx; Rpipx;
Species Mus musculus
Ensembl Protein ENSMUSP00000031229
InnateDB Gene IDBG-177275 (Rufy3)
Protein Structure
UniProt Annotation
Function Implicated in the formation of a single axon by developing neurons. May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes (By similarity). {ECO:0000250}.
Subcellular Localization Cell projection {ECO:0000250}. Note=Enriched in F-actin enriched filopodia and lamellipodia of growth cones of axons and minor processes of hippocampal neurons in culture. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0050771 negative regulation of axonogenesis
Cellular Component
GO:0030175 filopodium
GO:0030426 growth cone
Protein Structure and Domains
PDB ID MGI:106484
InterPro IPR004012 RUN
IPR009053 Prefoldin
PFAM PF02759
PRINTS
PIRSF
SMART SM00593
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D394
PhosphoSite PhosphoSite-Q9D394
TrEMBL
UniProt Splice Variant
Entrez Gene 52822
UniGene Mm.270469
RefSeq NP_081806
MGI ID 2DWK
MGI Symbol Rufy3
OMIM
CCDS CCDS19403
HPRD
IMGT
EMBL AK018184 AK083242 AK148795 AK154941 BC017648 BC049127 BC058259 CT010404
GenPept AAH17648 AAH49127 AAH58259 BAB31113 BAC38826 BAE28665 BAE32941 CAJ18610

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca