InnateDB Protein
|
IDBP-177296.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Ctu1
|
Protein Name
|
cytosolic thiouridylase subunit 1 homolog (S. pombe)
|
Synonyms
|
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000036770
|
InnateDB Gene
|
IDBG-177294 (Ctu1)
|
Protein Structure
|
|
Function |
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. {ECO:0000255HAMAP-Rule:MF_03053}.
|
Subcellular Localization |
Cytoplasm {ECO:0000255HAMAP-Rule:MF_03053}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
1
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
4 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:2385277
|
InterPro |
IPR011063
tRNA(Ile)-lysidine/2-thiocytidine synthase
|
PFAM |
PF01171
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q99J10
|
PhosphoSite |
PhosphoSite-Q99J10
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
233189
|
UniGene |
Mm.26514
|
RefSeq |
NP_663557
|
MGI ID |
|
MGI Symbol |
Ctu1
|
OMIM |
|
CCDS |
CCDS21179
|
HPRD |
|
IMGT |
|
EMBL |
AK155284
BC005752
|
GenPept |
AAH05752
BAE33164
|
|
|