InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lrrc41

Summary

InnateDB Protein

IDBP-177387.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lrrc41

Protein Name

leucine rich repeat containing 41

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030471

InnateDB Gene

IDBG-177385 (Lrrc41)

Protein Structure

UniProt Annotation

Function

Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0008150	biological_process
GO:0016567	protein ubiquitination

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:2441984

InterPro

IPR003590 Leucine-rich repeat, ribonuclease inhibitor subtype

PFAM

PRINTS

PIRSF

SMART

SM00368

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8K1C9

PhosphoSite

PhosphoSite-Q8K1C9

TrEMBL

Q3TCM6

UniProt Splice Variant

Entrez Gene

230654

UniGene

Mm.420526

RefSeq

NP_705741

MGI ID

MGI Symbol

Lrrc41

OMIM

CCDS

HPRD

IMGT

EMBL

AK154613 AK170641 AL627105 BC007169 BC022976 BC071258

GenPept

AAH07169 AAH22976 AAH71258 BAE32713 BAE41930 CAM22675