InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nfkbil1

Summary

InnateDB Protein

IDBP-177427.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nfkbil1

Protein Name

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1

Synonyms

Def-7; IKBL;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000035452

InnateDB Gene

IDBG-177425 (Nfkbil1)

Protein Structure

UniProt Annotation

Function

Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon- regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Note=Nuclear localization with a speckled expression pattern in some cells. Colocalizes with CACTIN in the nucleus (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

High expression found in heart muscle, liver, kidney and skin. Not detected in spleen, lung and brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0007249	I-kappaB kinase/NF-kappaB signaling
GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032720	negative regulation of tumor necrosis factor production
GO:0034122	negative regulation of toll-like receptor signaling pathway
GO:0071222	cellular response to lipopolysaccharide