InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lurap1

Summary

InnateDB Protein

IDBP-177471.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lurap1

Protein Name

RIKEN cDNA 1520402A15 gene

Synonyms

1520402A15Rik; Lrp35a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030469

InnateDB Gene

IDBG-177469 (Lurap1)

Protein Structure

UniProt Annotation

Function

Acts as an activator of the canonical NF-kappa-B pathway and drive the production of proinflammatory cytokines. Promotes the antigen (Ag)-presenting and priming function of dendritic cells via the canonical NF-kappa-B pathway. In concert with MYO18A and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Activates CDC42BPA/CDC42BPB and targets it to actomyosin through its interaction with MYO18A, leading to MYL9/MLC2 phosphorylation and MYH9/MYH10-dependent actomyosin assembly in the lamella (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0001819	positive regulation of cytokine production
GO:0016477	cell migration
GO:0031032	actomyosin structure organization
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling