Version 5.4
Mus musculus Protein: Mob1b
Summary
InnateDB Protein IDBP-177564.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mob1b
Protein Name MOB kinase activator 1B
Synonyms 1110003E08Rik; AU015450; B230364F10; Mobkl1a;
Species Mus musculus
Ensembl Protein ENSMUSP00000006424
InnateDB Gene IDBG-177562 (Mob1b)
Protein Structure
UniProt Annotation
Function Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019209 kinase activator activity
GO:0019900 kinase binding
GO:0046872 metal ion binding
Biological Process
GO:0035329 hippo signaling
GO:0042327 positive regulation of phosphorylation
GO:0046777 protein autophosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1915723
InterPro IPR005301 Mob1/phocein
PFAM PF03637
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BPB0
PhosphoSite PhosphoSite-Q8BPB0
TrEMBL Q3T9U1
UniProt Splice Variant
Entrez Gene 68473
UniGene Mm.419728
RefSeq NP_081011
MGI ID
MGI Symbol Mob1b
OMIM
CCDS CCDS39139
HPRD
IMGT
EMBL AK077320 AK162120 AK172291 BC104402 BC104403 CH466617
GenPept AAI04403 AAI04404 BAC36748 BAE36736 BAE42929 EDL05348

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca