InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Klk7

Summary

InnateDB Protein

IDBP-177570.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Klk7

Protein Name

kallikrein related-peptidase 7 (chymotryptic, stratum corneum)

Synonyms

Prss6; SCCE;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032955

InnateDB Gene

IDBG-177568 (Klk7)

Protein Structure

UniProt Annotation

Function

May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr--Gln-15' and insulin B chain at '6- Leu--Cys-7', '16-Tyr--Leu-17', '25-Phe--Tyr-26' and '26-Tyr-- Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in skin and, at lower levels, in lung, kidney, brain, heart and spleen. In skin, expressed in high suprabasal keratinocytes and in the luminal parts of hair follicles. Not detected in liver and skeletal muscle. {ECO:0000269PubMed:10469296}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity

Biological Process

GO:0006508

proteolysis

Cellular Component

GO:0005576	extracellular region
GO:0097209	epidermal lamellar body

Protein Structure and Domains

PDB ID

MGI:1346336

InterPro

IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain

PFAM

PF00089

PRINTS

PR00722

PIRSF

SMART

SM00020

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q91VE3

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

23993

UniGene

Mm.398924

RefSeq

NP_036002

MGI ID

MGI Symbol

Klk7

OMIM

CCDS

CCDS21183

HPRD

IMGT

EMBL

AB008371 AF124299 AF339930 AK029477 AK077406 BC027823

GenPept

AAF01139 AAH27823 AAK69652 BAB55604 BAC26467 BAC36787