InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rnf187

Summary

InnateDB Protein

IDBP-177573.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rnf187

Protein Name

ring finger protein 187

Synonyms

2410016F01Rik; AB030190; RACO-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000091703

InnateDB Gene

IDBG-177571 (Rnf187)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Shuttles between the cytoplasm and the nucleus. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0008270	zinc ion binding
GO:0016874	ligase activity

Biological Process

GO:0008284	positive regulation of cell proliferation
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0051865	protein autoubiquitination
GO:0070936	protein K48-linked ubiquitination