InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Esyt2

Summary

InnateDB Protein

IDBP-177791.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Esyt2

Protein Name

extended synaptotagmin-like protein 2

Synonyms

2410017M09Rik; 4921504I16Rik; CHR2SYT; D12Ertd551e; Fam62b;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000098548

InnateDB Gene

IDBG-177787 (Esyt2)

Protein Structure

UniProt Annotation

Function

Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Detected at sites of contact between the endoplasmic reticulum membrane and the cell membrane. Recruited to the cell membrane via the third C2 domain (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005544	calcium-dependent phospholipid binding
GO:0008429	phosphatidylethanolamine binding
GO:0031210	phosphatidylcholine binding
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0008150

biological_process

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0031227	intrinsic component of endoplasmic reticulum membrane
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0044232	organelle membrane contact site