Version 5.4
Mus musculus Protein: Ncapg2
Summary
InnateDB Protein IDBP-177929.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ncapg2
Protein Name non-SMC condensin II complex, subunit G2
Synonyms 5830426I05Rik; Luzp5; mCAP-G2; Mtb;
Species Mus musculus
Ensembl Protein ENSMUSP00000081889
InnateDB Gene IDBG-177927 (Ncapg2)
Protein Structure
UniProt Annotation
Function Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. Is required for early embryonic development and is essential for viability and expansion of the inner cell mass (ICM) of the implanting blastocyst. {ECO:0000269PubMed:14729962}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in spleen, lung and testis as well as in hematopoietic cell lines. {ECO:0000269PubMed:14729962}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0035064 methylated histone binding
Biological Process
GO:0001833 inner cell mass cell proliferation
GO:0007067 mitotic nuclear division
GO:0030261 chromosome condensation
Cellular Component
GO:0005634 nucleus
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:1923294
InterPro IPR016024 Armadillo-type fold
IPR024741 Condensin-2 complex subunit G2
PFAM PF12422
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6DFV1
PhosphoSite PhosphoSite-Q6DFV1
TrEMBL Q3UU24
UniProt Splice Variant
Entrez Gene 76044
UniGene Mm.484813
RefSeq NP_598523
MGI ID
MGI Symbol Ncapg2
OMIM
CCDS CCDS26212
HPRD
IMGT
EMBL AC160634 AK138871 AY455829 BC008539 BC076631 CT030173
GenPept AAH08539 AAH76631 AAR21588 BAE23805

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca