InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Vhl

Summary

InnateDB Protein

IDBP-178107.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vhl

Protein Name

von Hippel-Lindau tumor suppressor

Synonyms

Vhlh;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000039418

InnateDB Gene

IDBG-178105 (Vhl)

Protein Structure

UniProt Annotation

Function

Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia- inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Note=Colocalizes with ADRB2 at the cell membrane. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 355 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	355 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0032403	protein complex binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001525	angiogenesis
GO:0001666	response to hypoxia
GO:0006355	regulation of transcription, DNA-templated
GO:0010498	proteasomal protein catabolic process
GO:0016567	protein ubiquitination
GO:0030163	protein catabolic process
GO:0030182	neuron differentiation
GO:0030198	extracellular matrix organization
GO:0042069	regulation of catecholamine metabolic process
GO:0043534	blood vessel endothelial cell migration
GO:0045471	response to ethanol
GO:0051291	protein heterooligomerization
GO:0070243	regulation of thymocyte apoptotic process
GO:0070244	negative regulation of thymocyte apoptotic process
GO:2001233	regulation of apoptotic signaling pathway