InnateDB Protein
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IDBP-178337.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Cdca7l
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Protein Name
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cell division cycle associated 7 like
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000021592
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InnateDB Gene
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IDBG-178335 (Cdca7l)
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Protein Structure
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Function |
Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells (By similarity). Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1. {ECO:0000250, ECO:0000269PubMed:16829576}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in all tissues but not detected in total brain. {ECO:0000269PubMed:15994933}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
13 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2384982
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InterPro |
IPR018866
Zinc-finger domain of monoamine-oxidase A repressor R1
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PFAM |
PF10497
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q922M5
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PhosphoSite |
PhosphoSite-Q922M5
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
217946
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UniGene |
Mm.281149
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RefSeq |
NP_666152
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MGI ID |
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MGI Symbol |
Cdca7l
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OMIM |
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CCDS |
CCDS49197
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HPRD |
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IMGT |
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EMBL |
AK149673
BC006933
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GenPept |
AAH06933
BAE29017
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