InnateDB Protein
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IDBP-178481.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Slc38a4
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Protein Name
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solute carrier family 38, member 4
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Synonyms
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1110012E16Rik; 1700012A18Rik; Ata3; mATA3; mNAT3;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000023101
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InnateDB Gene
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IDBG-178479 (Slc38a4)
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Protein Structure
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Function |
Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by Ser, His, Gly, Cys, Asn, Thr, Pro, Gln and Met. May mediate sodium- independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with lower transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5. {ECO:0000269PubMed:12537539}.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:12537539}; Multi-pass membrane protein {ECO:0000269PubMed:12537539}.
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Disease Associations |
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Tissue Specificity |
Detected in liver, in hepatocytes surrounding the central vein. Not detected in heart, kidney, brain, lung, small intestine, spleen and thymus. {ECO:0000269PubMed:12537539}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0015171
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amino acid transmembrane transporter activity
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GO:0015293
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symporter activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1916604
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InterPro |
IPR013057
Amino acid transporter, transmembrane
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PFAM |
PF01490
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8R1S9
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PhosphoSite |
PhosphoSite-Q8R1S9
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
69354
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UniGene |
Mm.413402
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RefSeq |
NP_081328
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MGI ID |
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MGI Symbol |
Slc38a4
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OMIM |
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CCDS |
CCDS27779
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HPRD |
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IMGT |
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EMBL |
AB055004
AK051023
AK164292
AK167539
AK169349
AY027919
BC024072
BC024123
BC031717
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GenPept |
AAH24072
AAH24123
AAH31717
AAK21967
BAB84091
BAC34500
BAE37721
BAE39606
BAE41099
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