InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atp2b2

Summary

InnateDB Protein

IDBP-178519.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp2b2

Protein Name

ATPase, Ca++ transporting, plasma membrane 2

Synonyms

D6Abb2e; dfw; Gena300; jog; PMCA2; Tmy; wms; wri;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000098606

InnateDB Gene

IDBG-178513 (Atp2b2)

Protein Structure

UniProt Annotation

Function

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. Plays a role in maintaining balance and hearing. {ECO:0000269PubMed:9668038}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Note=Atp2b2 null deficient mice are deaf.

Tissue Specificity

Mainly expressed in brain cortex. Found at low levels in heart, liver, lung and testis during late gestation. Also found in cochlea (stereocilia and outer wall of hair cells).

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005388	calcium-transporting ATPase activity
GO:0005509	calcium ion binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0019829	cation-transporting ATPase activity
GO:0030165	PDZ domain binding
GO:0030899	calcium-dependent ATPase activity
GO:0046872	metal ion binding

Biological Process

GO:0000902	cell morphogenesis
GO:0006200	ATP catabolic process
GO:0006812	cation transport
GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0006996	organelle organization
GO:0007595	lactation
GO:0007605	sensory perception of sound
GO:0007626	locomotory behavior
GO:0008361	regulation of cell size
GO:0021549	cerebellum development
GO:0021692	cerebellar Purkinje cell layer morphogenesis
GO:0021702	cerebellar Purkinje cell differentiation
GO:0021707	cerebellar granule cell differentiation
GO:0030182	neuron differentiation
GO:0040011	locomotion
GO:0042428	serotonin metabolic process
GO:0042472	inner ear morphogenesis
GO:0045299	otolith mineralization
GO:0046068	cGMP metabolic process
GO:0048167	regulation of synaptic plasticity
GO:0048839	inner ear development
GO:0050808	synapse organization
GO:0050885	neuromuscular process controlling balance
GO:0050910	detection of mechanical stimulus involved in sensory perception of sound
GO:0051480	cytosolic calcium ion homeostasis
GO:0051928	positive regulation of calcium ion transport
GO:0060088	auditory receptor cell stereocilium organization
GO:0060113	inner ear receptor cell differentiation
GO:0070588	calcium ion transmembrane transport
GO:0090102	cochlea development

Cellular Component

GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0005929	cilium
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

MGI:105368

InterPro

IPR001757 Cation-transporting P-type ATPase
IPR004014 Cation-transporting P-type ATPase, N-terminal
IPR006068 Cation-transporting P-type ATPase, C-terminal
IPR006408 Calcium-transporting P-type ATPase, subfamily IIB
IPR008250 P-type ATPase, A domain
IPR022141 Calcium transporting P-type ATPase, C-terminal, plasma membrane
IPR023214 HAD-like domain
IPR023299 P-type ATPase, cytoplasmic domain N

PFAM