InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Brd7

Summary

InnateDB Protein

IDBP-178829.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Brd7

Protein Name

bromodomain containing 7

Synonyms

BP75; CELTIX1; Ptpn13ip;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034085

InnateDB Gene

IDBG-178827 (Brd7)

Protein Structure

UniProt Annotation

Function

Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase (By similarity). Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24- mediated activation of transcriptional activation by AR. {ECO:0000250, ECO:0000269PubMed:12941796, ECO:0000269PubMed:18809673, ECO:0000269PubMed:19909775}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:10526152, ECO:0000269PubMed:19909775}.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:10526152}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0003713	transcription coactivator activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0042393	histone binding
GO:0044212	transcription regulatory region DNA binding
GO:0070577	lysine-acetylated histone binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007049	cell cycle
GO:0008285	negative regulation of cell proliferation
GO:0016055	Wnt signaling pathway
GO:0035066	positive regulation of histone acetylation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle