InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc6a1

Summary

InnateDB Protein

IDBP-178839.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc6a1

Protein Name

solute carrier family 6 (neurotransmitter transporter, GABA), member 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032454

InnateDB Gene

IDBG-178837 (Slc6a1)

Protein Structure

UniProt Annotation

Function

Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localized at the plasma membrane and in a subset of intracellular vesicles (By similarity). Localized at the presynaptic terminals of interneurons. {ECO:0000250, ECO:0000269PubMed:15234345}.

Disease Associations

Tissue Specificity

Brain. Expressed in the dentate gyrus of hippocampus, striatum and cerebellum (at protein level). {ECO:0000269PubMed:15234345}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005328	neurotransmitter:sodium symporter activity
GO:0005332	gamma-aminobutyric acid:sodium symporter activity
GO:0005515	protein binding

Biological Process

GO:0006836	neurotransmitter transport
GO:0007612	learning
GO:0009636	response to toxic substance
GO:0009744	response to sucrose stimulus
GO:0010033	response to organic substance
GO:0010243	response to organonitrogen compound
GO:0010288	response to lead ion
GO:0014054	positive regulation of gamma-aminobutyric acid secretion
GO:0014070	response to organic cyclic compound
GO:0014074	response to purine-containing compound
GO:0032229	negative regulation of synaptic transmission, GABAergic
GO:0032355	response to estradiol
GO:0042220	response to cocaine
GO:0051260	protein homooligomerization
GO:0051592	response to calcium ion
GO:0051939	gamma-aminobutyric acid import
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0043005	neuron projection