InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GSG2

Summary

InnateDB Protein

IDBP-17891.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GSG2

Protein Name

germ cell associated 2 (haspin)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000325290

InnateDB Gene

IDBG-17889 (GSG2)

Protein Structure

UniProt Annotation

Function

Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. This positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. {ECO:0000269PubMed:11228240, ECO:0000269PubMed:15681610, ECO:0000269PubMed:17084365, ECO:0000269PubMed:20705812, ECO:0000269PubMed:20929775}.

Subcellular Localization

Nucleus. Chromosome. Cytoplasm, cytoskeleton, spindle. Note=Nuclear during interphase and associates with the chromosomes and spindle apparatus during mitosis.

Disease Associations

Tissue Specificity

Strongly expressed in testis. Also present in thymus and bone marrow and low levels observed in prostate, intestine, lung, spleen and lymph node. Expressed in fetal skin, liver, kidney and small intestine and also in proliferating but not non-proliferating cell lines. {ECO:0000269PubMed:11228240, ECO:0000269PubMed:11311556}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0072354	histone kinase activity (H3-T3 specific)

Biological Process

GO:0006468	protein phosphorylation
GO:0007064	mitotic sister chromatid cohesion
GO:0035556	intracellular signal transduction
GO:0071459	protein localization to chromosome, centromeric region
GO:0090231	regulation of spindle checkpoint
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle
GO:2000751	histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore

Cellular Component

GO:0005634	nucleus
GO:0005694	chromosome
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005819	spindle

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR024604 Domain of unknown function DUF3635

PFAM

PF00069
PF12330

PRINTS

PIRSF

SMART

SM00220

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8TF76