InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dlx1

Summary

InnateDB Protein

IDBP-178969.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dlx1

Protein Name

distal-less homeobox 1

Synonyms

Dlx; Dlx-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000042413

InnateDB Gene

IDBG-178967 (Dlx1)

Protein Structure

UniProt Annotation

Function

Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}.

Disease Associations

Tissue Specificity

Expressed in a restricted region of the developing brain, within the diencephalon and the adjacent telencephalic regions.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0009954	proximal/distal pattern formation
GO:0021544	subpallium development
GO:0021766	hippocampus development
GO:0021879	forebrain neuron differentiation
GO:0021882	regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment
GO:0021892	cerebral cortex GABAergic interneuron differentiation
GO:0021893	cerebral cortex GABAergic interneuron fate commitment
GO:0030154	cell differentiation
GO:0042475	odontogenesis of dentin-containing tooth
GO:0043524	negative regulation of neuron apoptotic process
GO:0045746	negative regulation of Notch signaling pathway
GO:0048706	embryonic skeletal system development
GO:0048715	negative regulation of oligodendrocyte differentiation