InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Epgn

Summary

InnateDB Protein

IDBP-178995.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Epgn

Protein Name

epithelial mitogen

Synonyms

2310069M11Rik; epigen;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000046987

InnateDB Gene

IDBG-178993 (Epgn)

Protein Structure

UniProt Annotation

Function

Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed at low levels in testis, heart and liver. {ECO:0000269PubMed:11278323}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004708	MAP kinase kinase activity
GO:0005154	epidermal growth factor receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0000165	MAPK cascade
GO:0000187	activation of MAPK activity
GO:0001525	angiogenesis
GO:0008284	positive regulation of cell proliferation
GO:0043406	positive regulation of MAP kinase activity
GO:0045741	positive regulation of epidermal growth factor-activated receptor activity
GO:0045840	positive regulation of mitosis
GO:0050679	positive regulation of epithelial cell proliferation